Does seasonal variation affect hallucinations in PD? a longitudinal study
Identifieur interne : 003480 ( Main/Exploration ); précédent : 003479; suivant : 003481Does seasonal variation affect hallucinations in PD? a longitudinal study
Auteurs : Christopher G. Goetz [États-Unis] ; John Michael Li [États-Unis] ; Joanne Wuu [États-Unis] ; Sue Leurgans [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-06-06.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Chronobiology, Darkness, Female, Hallucination, Hallucinations (epidemiology), Hallucinations (physiopathology), Humans, Light, Longitudinal Studies, Male, Nervous system diseases, Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Seasonal variation, Seasons, Severity of Illness Index, chronobiology, hallucinations.
- MESH :
- epidemiology : Hallucinations.
- physiopathology : Hallucinations.
- psychology : Parkinson Disease.
- Darkness, Female, Humans, Light, Longitudinal Studies, Male, Seasons, Severity of Illness Index.
Abstract
The objective of this study was to examine the chronobiology of visual hallucinations in Parkinson's disease (PD) patients to test whether hallucinations are more severe during darker months (winter) than summer months. We extracted longitudinal data on the UPDRS Thought Disorder (TD) score, taken as part of regular patient management on sequential visits through a 1‐year cycle in hallucinating PD patients. To reduce the confounding effects of medication adjustments, analysis was restricted to patients with a baseline evaluation that did not involve a medication change. The primary outcome was the seasonal change in hallucination severity, defined as a change in TD score or neuroleptic use. Using Wilcoxon rank‐sum tests, we compared the exacerbation of hallucination by season, focusing on winter (December through February) versus summer (June through August). A total of 51 hallucinating patients met entry criteria, and their longitudinal data were analyzed. There was no difference in hallucination severity with changing season; the level of wintertime exacerbation was no greater than summertime exacerbation (P = 0.42). Although hallucinations frequently develop in dimmed environments and evening hours, the darkness of wintertime does not exacerbate hallucinations in PD subjects on stable medications. Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20840
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-06-06">2006-06-06</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="863">863</biblScope><biblScope unit="page" to="865">865</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2D8BB97A16ADA9CF1F8B6003448406CD389DE058</idno><idno type="DOI">10.1002/mds.20840</idno><idno type="ArticleID">MDS20840</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chronobiology</term><term>Darkness</term><term>Female</term><term>Hallucination</term><term>Hallucinations (epidemiology)</term><term>Hallucinations (physiopathology)</term><term>Humans</term><term>Light</term><term>Longitudinal Studies</term><term>Male</term><term>Nervous system diseases</term><term>Parkinson Disease (psychology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Seasonal variation</term><term>Seasons</term><term>Severity of Illness Index</term><term>chronobiology</term><term>hallucinations</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hallucinations</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hallucinations</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Darkness</term><term>Female</term><term>Humans</term><term>Light</term><term>Longitudinal Studies</term><term>Male</term><term>Seasons</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chronobiologie</term><term>Hallucination</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term><term>Variation saisonnière</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to examine the chronobiology of visual hallucinations in Parkinson's disease (PD) patients to test whether hallucinations are more severe during darker months (winter) than summer months. We extracted longitudinal data on the UPDRS Thought Disorder (TD) score, taken as part of regular patient management on sequential visits through a 1‐year cycle in hallucinating PD patients. To reduce the confounding effects of medication adjustments, analysis was restricted to patients with a baseline evaluation that did not involve a medication change. The primary outcome was the seasonal change in hallucination severity, defined as a change in TD score or neuroleptic use. Using Wilcoxon rank‐sum tests, we compared the exacerbation of hallucination by season, focusing on winter (December through February) versus summer (June through August). A total of 51 hallucinating patients met entry criteria, and their longitudinal data were analyzed. There was no difference in hallucination severity with changing season; the level of wintertime exacerbation was no greater than summertime exacerbation (P = 0.42). Although hallucinations frequently develop in dimmed environments and evening hours, the darkness of wintertime does not exacerbate hallucinations in PD subjects on stable medications. Because we found no evidence of seasonal variations, we cannot recommend phototherapy or other strategies affecting chronobiological systems as research priorities to treat PD hallucinations. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name></region><name sortKey="Leurgans, Sue" sort="Leurgans, Sue" uniqKey="Leurgans S" first="Sue" last="Leurgans">Sue Leurgans</name><name sortKey="Li, John Michael" sort="Li, John Michael" uniqKey="Li J" first="John Michael" last="Li">John Michael Li</name><name sortKey="Wuu, Joanne" sort="Wuu, Joanne" uniqKey="Wuu J" first="Joanne" last="Wuu">Joanne Wuu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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